Redmine

when using redmine,this problem happend sometimes,and will be OK after few minutes.
IE shows like this: "server unable to read htaccess file,deying access to be safe..." or like this: "500 error"
I have set apache conf file and remine conf file to "granted all granted"
now this problem happens again,the error log is:[attachement is the whole error log]

Thank you very much!
Regards,
wdq

App 32019 stderr: from /home/wdq/redmine-3.3.0-1/ruby/lib/ruby/gems/2.1.0/gems/passenger-5.0.6/lib/phusion_passenger/request_handler.rb:179:in `main_loop'
App 32019 stderr: from /home/wdq/redmine-3.3.0-1/ruby/lib/ruby/gems/2.1.0/gems/passenger-5.0.6/helper-scripts/rack-preloader.rb:160:in `<module:App>'
App 32019 stderr: from /home/wdq/redmine-3.3.0-1/ruby/lib/ruby/gems/2.1.0/gems/passenger-5.0.6/helper-scripts/rack-preloader.rb:29:in `<module:PhusionPassenger>'
App 32019 stderr: from /home/wdq/redmine-3.3.0-1/ruby/lib/ruby/gems/2.1.0/gems/passenger-5.0.6/helper-scripts/rack-preloader.rb:28:in `<main>'
App 32019 stderr: [WARN] mysql2 failed to invalidate FD safely
[ 2016-08-31 19:06:03.0177 15911/7ff201cde700 App/Poo/AnalyticsCollection.h:93 ]: Process (pid=32051, group=/home/wdq/redmine-3.3.0-1/apps/redmine/htdocs/#default) no longer exists! Detaching it from the pool.
[ 2016-08-31 19:06:03.0178 15911/7ff201cde700 age/Hel/Main.cpp:732 ]: Disconnecting long-running connections for process 32051, application /home/wdq/redmine-3.3.0-1/apps/redmine/htdocs/#default
[Wed Aug 31 19:06:37.539452 2016] [core:error] [pid 24979] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:37.540137 2016] [core:error] [pid 24879] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:37.543512 2016] [core:error] [pid 24874] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:37.543578 2016] [core:error] [pid 25008] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:37.546117 2016] [core:error] [pid 24877] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:37.549118 2016] [core:error] [pid 24887] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:38.006515 2016] [:error] [pid 24873] [client 99.0.36.117:49570] PHP Warning: include(/home/wdq/redmine-3.3.0-1/apps/phpmyadmin/htdocs/libraries/Error.php): failed to open stream: Too many open files in system in /home/wdq/redmine-3.3.0-1/apps/phpmyadmin/htdocs/libraries/Psr4Autoloader.php on line 166, referer: http://99.12.143.173:8080/phpmyadmin/
[Wed Aug 31 19:06:38.006615 2016] [:error] [pid 24873] [client 99.0.36.117:49570] PHP Warning: include(): Failed opening './libraries/Error.php' for inclusion (include_path='.:/home/wdq/redmine-3.3.0-1/php/lib/php') in /home/wdq/redmine-3.3.0-1/apps/phpmyadmin/htdocs/libraries/Psr4Autoloader.php on line 166, referer: http://99.12.143.173:8080/phpmyadmin/
[Wed Aug 31 19:06:38.006638 2016] [:error] [pid 24873] [client 99.0.36.117:49570] PHP Fatal error: Class 'PMA\\libraries\\Error' not found in /home/wdq/redmine-3.3.0-1/apps/phpmyadmin/htdocs/libraries/ErrorHandler.php on line 167, referer: http://99.12.143.173:8080/phpmyadmin/
[Wed Aug 31 19:06:38.008594 2016] [pagespeed:error] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] /home/wdq/redmine-3.3.0-1/apache2/var/cache/mod_pagespeed/v2/99.12.143.173/http,3A/,2F99.12.143.173,3A8080/phpmyadmin/js/messages.php,3Flang=zh_CN,26db=,26token=e3b90209f3a5ff361cc85c844c6ff641,26v=4.6.2,.temprmOXtx:0: opening temp file: Too many open files in system
[Wed Aug 31 19:06:38.010304 2016] [core:error] [pid 24873] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:38.020493 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed @24873] [0831/190638:WARNING:serf_url_async_fetcher.cc(1235)] Aborting fetch of http://99.12.143.173:8080/phpmyadmin/js/get_scripts.js.php?scripts%5B%5D=jquery/jquery.debounce-1.0.5.js&scripts%5B%5D=menu-resizer.js&scripts%5B%5D=cross_framing_protection.js&scripts%5B%5D=rte.js&scripts%5B%5D=tracekit/tracekit.js&scripts%5B%5D=error_report.js&scripts%5B%5D=config.js&scripts%5B%5D=doclinks.js&scripts%5B%5D=functions.js&scripts%5B%5D=navigation.js&v=4.6.2
[Wed Aug 31 19:06:38.020630 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/js/get_scripts.js.php?scripts%5B%5D=indexes.js&scripts%5B%5D=common.js&scripts%5B%5D=page_settings.js&scripts%5B%5D=codemirror/lib/codemirror.js&scripts%5B%5D=codemirror/mode/sql/sql.js&scripts%5B%5D=codemirror/addon/runmode/runmode.js&scripts%5B%5D=codemirror/addon/hint/show-hint.js&scripts%5B%5D=codemirror/addon/hint/sql-hint.js&scripts%5B%5D=codemirror/addon/lint/lint.js&scripts%5B%5D=codemirror/addon/lint/sql-lint.js&v=4.6.2 on shutdown
[Wed Aug 31 19:06:38.020712 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/js/get_scripts.js.php?scripts%5B%5D=console.js&v=4.6.2 on shutdown
[Wed Aug 31 19:06:38.020778 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/js/messages.php?lang=zh_CN&db=&token=e3b90209f3a5ff361cc85c844c6ff641&v=4.6.2 on shutdown
[Wed Aug 31 19:06:38.020844 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/js/get_image.js.php?theme=pmahomme&v=4.6.2 on shutdown
[Wed Aug 31 19:06:38.020909 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/favicon.ico on shutdown
[Wed Aug 31 19:06:38.020996 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/img/logo_right.png on shutdown
[Wed Aug 31 19:06:38.021064 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/dot.gif on shutdown
[Wed Aug 31 19:06:38.021152 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/phpmyadmin.css.php?nocache=4399033929ltr on shutdown
[Wed Aug 31 19:06:38.021205 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_highlight-soft_75_cccccc_1x100.png on shutdown
[Wed Aug 31 19:06:38.021250 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_glass_75_e6e6e6_1x400.png on shutdown
[Wed Aug 31 19:06:38.021311 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_glass_75_dadada_1x400.png on shutdown
[Wed Aug 31 19:06:38.021434 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_glass_65_ffffff_1x400.png on shutdown
[Wed Aug 31 19:06:38.021516 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_glass_55_fbf9ee_1x400.png on shutdown
[Wed Aug 31 19:06:38.021579 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-bg_glass_95_fef1ec_1x400.png on shutdown
[Wed Aug 31 19:06:38.021659 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-icons_222222_256x240.png on shutdown
[Wed Aug 31 19:06:38.021728 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-icons_888888_256x240.png on shutdown
[Wed Aug 31 19:06:38.021793 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-icons_454545_256x240.png on shutdown
[Wed Aug 31 19:06:38.021838 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-icons_2e83ff_256x240.png on shutdown
[Wed Aug 31 19:06:38.021920 2016] [pagespeed:warn] [pid 24873] [mod_pagespeed 1.9.32.14-0 @24873] RateController: drop deferred fetch of http://99.12.143.173:8080/phpmyadmin/themes/pmahomme/jquery/images/ui-icons_cd0a0a_256x240.png on shutdown
[Wed Aug 31 19:06:41.257522 2016] [mpm_prefork:emerg] [pid 32128] (23)Too many open files in system: AH00156: Couldn't create pollset in child; check system or user limits
[Wed Aug 31 19:06:41.257628 2016] [mpm_prefork:emerg] [pid 32127] (23)Too many open files in system: AH00156: Couldn't create pollset in child; check system or user limits
[Wed Aug 31 19:06:42.258799 2016] [core:error] [pid 32131] (23)Too many open files in system: AH02179: apr_socket_accept: (client socket)
[Wed Aug 31 19:06:42.259619 2016] [mpm_prefork:emerg] [pid 32134] (23)Too many open files in system: AH00156: Couldn't create pollset in child; check system or user limits
[Wed Aug 31 19:06:42.264367 2016] [pagespeed:error] [pid 32132] [mod_pagespeed 1.9.32.14-0 @32132] /dev/urandom:0: opening input file: Too many open files in system
[Wed Aug 31 19:06:42.264835 2016] [pagespeed:alert] [pid 32132] [mod_pagespeed 1.9.32.14-0 @32132] [0831/190642:FATAL:system_rewrite_driver_factory.cc(204)] Check failed: random_file != NULL. Couldn't open /dev/urandom\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8e19e) [0x7fcc6bfa019e]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x84eb3) [0x7fcc6bf96eb3]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8ed52) [0x7fcc6bfa0d52]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x3333df) [0x7fcc6c2453df]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xaec69) [0x7fcc6bfc0c69]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xaf967) [0x7fcc6bfc1967]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xb24f2) [0x7fcc6bfc44f2]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x33d527) [0x7fcc6c24f527]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x3335cd) [0x7fcc6c2455cd]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x7aa95) [0x7fcc6bf8ca95]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8a14e) [0x7fcc6bf9c14e]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(ap_run_child_init+0x59) [0x4598a2]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x3cad) [0x7fcc74345cad]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x43db) [0x7fcc743463db]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x489b) [0x7fcc7434689b]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x510d) [0x7fcc7434710d]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(ap_run_mpm+0x68) [0x43272b]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(main+0x1014) [0x42a92b]\n/lib64/libc.so.6(_libc_start_main+0xfd) [0x327dc1ed5d]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin() [0x428919]
[Wed Aug 31 19:06:42.265014 2016] [pagespeed:error] [pid 32133] [mod_pagespeed 1.9.32.14-0 @32133] /dev/urandom:0: opening input file: Too many open files in system
[Wed Aug 31 19:06:42.265415 2016] [pagespeed:alert] [pid 32133] [mod_pagespeed 1.9.32.14-0 @32133] [0831/190642:FATAL:system_rewrite_driver_factory.cc(204)] Check failed: random_file != NULL. Couldn't open /dev/urandom\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8e19e) [0x7fcc6bfa019e]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x84eb3) [0x7fcc6bf96eb3]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8ed52) [0x7fcc6bfa0d52]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x3333df) [0x7fcc6c2453df]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xaec69) [0x7fcc6bfc0c69]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xaf967) [0x7fcc6bfc1967]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0xb24f2) [0x7fcc6bfc44f2]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x33d527) [0x7fcc6c24f527]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x3335cd) [0x7fcc6c2455cd]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x7aa95) [0x7fcc6bf8ca95]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_pagespeed_ap24.so(+0x8a14e) [0x7fcc6bf9c14e]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(ap_run_child_init+0x59) [0x4598a2]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x3cad) [0x7fcc74345cad]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x43db) [0x7fcc743463db]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x489b) [0x7fcc7434689b]\n/home/wdq/redmine-3.3.0-1/apache2/modules/mod_mpm_prefork.so(+0x510d) [0x7fcc7434710d]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(ap_run_mpm+0x68) [0x43272b]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin(main+0x1014) [0x42a92b]\n/lib64/libc.so.6(_libc_start_main+0xfd) [0x327dc1ed5d]\n/home/wdq/redmine-3.3.0-1/apache2/bin/httpd.bin() [0x428919]
[Wed Aug 31 19:06:43.259414 2016] [core:notice] [pid 15894] AH00052: child pid 32132 exit signal Aborted (6)
[Wed Aug 31 19:06:43.259509 2016] [core:notice] [pid 15894] AH00052: child pid 32133 exit signal Aborted (6)